Drug interactions
acitretin + aminolevulinic acid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Acitretin can cause photosensitivity, and oral aminolevulinic acid produces protoporphyrin-related phototoxicity. Together they raise the risk of skin phototoxic reactions after light exposure.
Mechanism of action
Additive photosensitizing effects through pharmacodynamic synergism.
Clinical management
Avoid giving acitretin in the perioperative period around oral aminolevulinic acid. Instruct the patient to protect skin and eyes from light.
Drug reference
Frequently asked questions
Can I take acitretin with aminolevulinic acid?
The interaction is rated: Major. Acitretin can cause photosensitivity, and oral aminolevulinic acid produces protoporphyrin-related phototoxicity. Together they raise the risk of skin phototoxic reactions after light exposure.
How serious is the interaction between acitretin and aminolevulinic acid?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between acitretin and aminolevulinic acid managed?
Avoid giving acitretin in the perioperative period around oral aminolevulinic acid. Instruct the patient to protect skin and eyes from light.
Why do acitretin and aminolevulinic acid interact?
Additive photosensitizing effects through pharmacodynamic synergism.
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