Drug interactions
aminolevulinic acid + chlorpropamide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Chlorpropamide, like other sulfonylureas, can occasionally cause photosensitivity, so phototoxicity may be additive.
Mechanism of action
Additive photosensitizing effects of protoporphyrin accumulation and sulfonylurea-related photosensitivity.
Clinical management
Counsel the patient to avoid sunlight and bright light exposure for the period specified in the aminolevulinic acid labeling. Monitor the skin for reactions and avoid adding other phototoxic drugs in the 24 hours around the procedure.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with chlorpropamide?
The interaction is rated: Moderate. Oral aminolevulinic acid used for visualization in surgery causes transient skin photosensitivity. Chlorpropamide, like other sulfonylureas, can occasionally cause photosensitivity, so phototoxicity may be additive.
How serious is the interaction between aminolevulinic acid and chlorpropamide?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and chlorpropamide managed?
Counsel the patient to avoid sunlight and bright light exposure for the period specified in the aminolevulinic acid labeling. Monitor the skin for reactions and avoid adding other phototoxic drugs in the 24 hours around the procedure.
Why do aminolevulinic acid and chlorpropamide interact?
Additive photosensitizing effects of protoporphyrin accumulation and sulfonylurea-related photosensitivity.
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