Drug interactions
aminolevulinic acid + ciprofloxacin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid used for fluorescence-guided surgery causes photosensitivity through protoporphyrin accumulation. Ciprofloxacin is also phototoxic, so the skin reaction risk may be additive. This is relevant in the perioperative period when patients are exposed to light.
Mechanism of action
Additive phototoxicity from protoporphyrin sensitization and quinolone-induced photosensitivity.
Clinical management
Avoid giving ciprofloxacin during the 24-hour perioperative period after aminolevulinic acid where an alternative exists. Advise strict sun and bright-light protection.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with ciprofloxacin?
The interaction is rated: Moderate. Oral aminolevulinic acid used for fluorescence-guided surgery causes photosensitivity through protoporphyrin accumulation. Ciprofloxacin is also phototoxic, so the skin reaction risk may be additive. This is relevant in the perioperative period when patients are exposed to light.
How serious is the interaction between aminolevulinic acid and ciprofloxacin?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and ciprofloxacin managed?
Avoid giving ciprofloxacin during the 24-hour perioperative period after aminolevulinic acid where an alternative exists. Advise strict sun and bright-light protection.
Why do aminolevulinic acid and ciprofloxacin interact?
Additive phototoxicity from protoporphyrin sensitization and quinolone-induced photosensitivity.
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