Drug interactions
aminolevulinic acid + glipizide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid used for imaging in surgery causes transient photosensitivity, and sulfonylureas such as glipizide are reported to cause photosensitivity. Combined use may heighten the risk of phototoxic skin reactions during the perioperative period.
Mechanism of action
Additive photosensitizing effects from protoporphyrin accumulation and drug-related photosensitivity.
Clinical management
Avoid exposing skin and eyes to strong light for the period advised in the aminolevulinic acid labeling. Hold glipizide in the perioperative window per usual fasting practice and monitor glucose.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with glipizide?
The interaction is rated: Moderate. Oral aminolevulinic acid used for imaging in surgery causes transient photosensitivity, and sulfonylureas such as glipizide are reported to cause photosensitivity. Combined use may heighten the risk of phototoxic skin reactions during the perioperative period.
How serious is the interaction between aminolevulinic acid and glipizide?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and glipizide managed?
Avoid exposing skin and eyes to strong light for the period advised in the aminolevulinic acid labeling. Hold glipizide in the perioperative window per usual fasting practice and monitor glucose.
Why do aminolevulinic acid and glipizide interact?
Additive photosensitizing effects from protoporphyrin accumulation and drug-related photosensitivity.
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