Drug interactions
aminolevulinic acid + griseofulvin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Griseofulvin can cause photosensitivity, and oral aminolevulinic acid induces protoporphyrin IX accumulation that causes phototoxicity. Using them together may increase the risk of skin photosensitivity reactions.
Mechanism of action
Additive phototoxic or photosensitizing effects.
Clinical management
Avoid other photosensitizing drugs around the time of aminolevulinic acid dosing, and advise strict sun and bright light protection. Consider delaying griseofulvin if the procedure is elective.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with griseofulvin?
The interaction is rated: Moderate. Griseofulvin can cause photosensitivity, and oral aminolevulinic acid induces protoporphyrin IX accumulation that causes phototoxicity. Using them together may increase the risk of skin photosensitivity reactions.
How serious is the interaction between aminolevulinic acid and griseofulvin?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and griseofulvin managed?
Avoid other photosensitizing drugs around the time of aminolevulinic acid dosing, and advise strict sun and bright light protection. Consider delaying griseofulvin if the procedure is elective.
Why do aminolevulinic acid and griseofulvin interact?
Additive phototoxic or photosensitizing effects.
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