Drug interactions
aminolevulinic acid + hydrochlorothiazide-olmesartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity as well. Using them together may raise the risk of phototoxic skin reactions after exposure to light.
Mechanism of action
Additive photosensitizing effects of two agents.
Clinical management
Strictly follow light-avoidance precautions for the period specified in the aminolevulinic acid labeling. Consider holding the thiazide in the perioperative period if clinically feasible.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with hydrochlorothiazide-olmesartan?
The interaction is rated: Moderate. Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity as well. Using them together may raise the risk of phototoxic skin reactions after exposure to light.
How serious is the interaction between aminolevulinic acid and hydrochlorothiazide-olmesartan?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and hydrochlorothiazide-olmesartan managed?
Strictly follow light-avoidance precautions for the period specified in the aminolevulinic acid labeling. Consider holding the thiazide in the perioperative period if clinically feasible.
Why do aminolevulinic acid and hydrochlorothiazide-olmesartan interact?
Additive photosensitizing effects of two agents.
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