Drug interactions
aminolevulinic acid + ketorolac
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes accumulation of photosensitizing protoporphyrin, and other phototoxic drugs may add to the risk of skin photosensitivity reactions. NSAIDs like ketorolac have some photosensitizing potential, though this is generally low for ketorolac. The concern is mainly theoretical and relevant in the perioperative period.
Mechanism of action
Additive phototoxic potential from drugs that sensitize the skin to light.
Clinical management
Avoid giving other potentially phototoxic drugs for 24 hours after oral aminolevulinic acid where alternatives exist. Counsel the patient to protect skin and eyes from light exposure during that time.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with ketorolac?
The interaction is rated: Moderate. Oral aminolevulinic acid causes accumulation of photosensitizing protoporphyrin, and other phototoxic drugs may add to the risk of skin photosensitivity reactions. NSAIDs like ketorolac have some photosensitizing potential, though this is generally low for ketorolac. The concern is mainly theoretical and relevant in the perioperative period.
How serious is the interaction between aminolevulinic acid and ketorolac?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and ketorolac managed?
Avoid giving other potentially phototoxic drugs for 24 hours after oral aminolevulinic acid where alternatives exist. Counsel the patient to protect skin and eyes from light exposure during that time.
Why do aminolevulinic acid and ketorolac interact?
Additive phototoxic potential from drugs that sensitize the skin to light.
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