Drug interactions
Amlodipine/Valsartan/Hydrochlorothiazide + Linagliptin/Metformin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide may impair glycemic control, reducing the glucose-lowering effect of linagliptin/metformin.
Mechanism of action
Thiazide diuretics decrease insulin sensitivity and may increase hepatic glucose output; hypokalemia may further impair insulin secretion.
Clinical management
Monitor fasting glucose and HbA1c after initiation or dose changes of HCTZ; adjust antidiabetic therapy as needed; correct hypokalemia if present.
References
- Hydrochlorothiazide Prescribing Information — FDA Label
- Exforge HCT (amlodipine/valsartan/hydrochlorothiazide) Prescribing Information — FDA Label
- Metformin (Glucophage) Prescribing Information — FDA Label
Frequently asked questions
Can I take Amlodipine/Valsartan/Hydrochlorothiazide with Linagliptin/Metformin?
The interaction is rated: Moderate. Hydrochlorothiazide may impair glycemic control, reducing the glucose-lowering effect of linagliptin/metformin.
How serious is the interaction between Amlodipine/Valsartan/Hydrochlorothiazide and Linagliptin/Metformin?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Amlodipine/Valsartan/Hydrochlorothiazide and Linagliptin/Metformin managed?
Monitor fasting glucose and HbA1c after initiation or dose changes of HCTZ; adjust antidiabetic therapy as needed; correct hypokalemia if present.
Why do Amlodipine/Valsartan/Hydrochlorothiazide and Linagliptin/Metformin interact?
Thiazide diuretics decrease insulin sensitivity and may increase hepatic glucose output; hypokalemia may further impair insulin secretion.
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