Drug interactions
Artemether + Milk
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Milk (fat-containing food) increases the oral absorption/exposure of artemether; taking doses with milk can improve antimalarial efficacy, while taking on an empty stomach may reduce exposure.
Mechanism of action
Pharmacokinetic: Increased solubilization of lipophilic artemether and bile-stimulated absorption with fatty food/milk, raising Cmax and AUC.
Clinical management
Administer oral artemether-containing doses with milk or other food to enhance absorption. If not feasible, give with water and encourage food intake as soon as possible; monitor clinical response.
References
- Coartem (artemether and lumefantrine) tablets, Prescribing Information — FDA Label
- Riamet (artemether/lumefantrine) tablets, Summary of Product Characteristics — EMA
Frequently asked questions
Can I take Artemether with Milk?
The interaction is rated: Moderate. Milk (fat-containing food) increases the oral absorption/exposure of artemether; taking doses with milk can improve antimalarial efficacy, while taking on an empty stomach may reduce exposure.
How serious is the interaction between Artemether and Milk?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Artemether and Milk managed?
Administer oral artemether-containing doses with milk or other food to enhance absorption. If not feasible, give with water and encourage food intake as soon as possible; monitor clinical response.
Why do Artemether and Milk interact?
Pharmacokinetic: Increased solubilization of lipophilic artemether and bile-stimulated absorption with fatty food/milk, raising Cmax and AUC.
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