Drug interactions
aspirin + cyclosporine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
NSAIDs, including aspirin, may potentiate cyclosporine-associated nephrotoxicity and impair renal function.
Mechanism of action
Pharmacodynamic: NSAID-induced afferent arteriolar constriction plus cyclosporine renal vasoconstriction → additive reduction in renal blood flow/GFR.
Clinical management
Avoid chronic/high-dose NSAIDs. If low-dose aspirin is required for antiplatelet therapy, use the lowest effective dose and monitor serum creatinine/eGFR (and cyclosporine troughs) periodically.
References
- Cyclosporine (Sandimmune/Neoral) Prescribing Information — FDA Label
- Lexicomp Interaction Monograph: Cyclosporine + NSAIDs — Lexicomp
- UpToDate: Nephrotoxicity of calcineurin inhibitors — UpToDate
Frequently asked questions
Can I take aspirin with cyclosporine?
The interaction is rated: Major. NSAIDs, including aspirin, may potentiate cyclosporine-associated nephrotoxicity and impair renal function.
How serious is the interaction between aspirin and cyclosporine?
The interaction is rated: Major. Evidence level: High.
How is the interaction between aspirin and cyclosporine managed?
Avoid chronic/high-dose NSAIDs. If low-dose aspirin is required for antiplatelet therapy, use the lowest effective dose and monitor serum creatinine/eGFR (and cyclosporine troughs) periodically.
Why do aspirin and cyclosporine interact?
Pharmacodynamic: NSAID-induced afferent arteriolar constriction plus cyclosporine renal vasoconstriction → additive reduction in renal blood flow/GFR.
Full monographs, dosing and an interaction checker in the MediHelp app
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