Drug interactions
aspirin + valsartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Aspirin (as an NSAID) may attenuate valsartan’s antihypertensive effect and increase risk of renal impairment, especially with chronic/high doses or in at-risk patients.
Mechanism of action
Renal prostaglandin inhibition by aspirin → afferent arteriolar constriction, sodium/water retention; combined with ARB-mediated efferent dilation → reduced GFR and blunted BP response.
Clinical management
Avoid chronic/high-dose aspirin if possible. If low-dose antiplatelet therapy is needed, use the lowest effective dose and monitor BP, serum creatinine/eGFR, and potassium within 1–2 weeks of initiation or dose change and periodically.
Drug reference
References
- Diovan (valsartan) Prescribing Information — FDA Label
- Valsartan—Drug Interactions: NSAIDs/salicylates — Lexicomp
- Avoiding the ‘triple whammy’ of ACE inhibitor/ARB, diuretic, and NSAID — SPS
Frequently asked questions
Can I take aspirin with valsartan?
The interaction is rated: Moderate. Aspirin (as an NSAID) may attenuate valsartan’s antihypertensive effect and increase risk of renal impairment, especially with chronic/high doses or in at-risk patients.
How serious is the interaction between aspirin and valsartan?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between aspirin and valsartan managed?
Avoid chronic/high-dose aspirin if possible. If low-dose antiplatelet therapy is needed, use the lowest effective dose and monitor BP, serum creatinine/eGFR, and potassium within 1–2 weeks of initiation or dose change and periodically.
Why do aspirin and valsartan interact?
Renal prostaglandin inhibition by aspirin → afferent arteriolar constriction, sodium/water retention; combined with ARB-mediated efferent dilation → reduced GFR and blunted BP response.
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