Drug interactions
Atorvastatin/Amlodipine + Nitroglycerin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive vasodilation can lead to marked hypotension, dizziness, syncope, and headache when nitroglycerin is used with amlodipine.
Mechanism of action
Pharmacodynamic additive vasodilation (nitrate-mediated venodilation/arterial dilation plus dihydropyridine CCB arterial dilation).
Clinical management
Use lowest effective nitrate dose; monitor BP, especially with initiation or dose changes; advise patient to sit/lie down when using sublingual nitroglycerin.
Drug reference
References
- Nitroglycerin Sublingual Tablets: Prescribing Information (Warnings: Severe hypotension with other vasodilators) — FDA Label
- Amlodipine: Drug Information — Lexicomp
- Nitrates in the management of stable angina — UpToDate
Frequently asked questions
Can I take Atorvastatin/Amlodipine with Nitroglycerin?
The interaction is rated: Moderate. Additive vasodilation can lead to marked hypotension, dizziness, syncope, and headache when nitroglycerin is used with amlodipine.
How serious is the interaction between Atorvastatin/Amlodipine and Nitroglycerin?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Atorvastatin/Amlodipine and Nitroglycerin managed?
Use lowest effective nitrate dose; monitor BP, especially with initiation or dose changes; advise patient to sit/lie down when using sublingual nitroglycerin.
Why do Atorvastatin/Amlodipine and Nitroglycerin interact?
Pharmacodynamic additive vasodilation (nitrate-mediated venodilation/arterial dilation plus dihydropyridine CCB arterial dilation).
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