Drug interactions
clarithromycin + cyclosporine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ cyclosporine levels → nephrotoxicity.
Mechanism of action
CYP3A4/P-gp inhibition.
Clinical management
Avoid or reduce dose; monitor levels and renal function.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with cyclosporine?
The interaction is rated: Major. ↑ cyclosporine levels → nephrotoxicity.
How serious is the interaction between clarithromycin and cyclosporine?
The interaction is rated: Major. Evidence level: High.
How is the interaction between clarithromycin and cyclosporine managed?
Avoid or reduce dose; monitor levels and renal function.
Why do clarithromycin and cyclosporine interact?
CYP3A4/P-gp inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.