Drug interactions
clozapine + valproate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ clozapine levels/sedation; rare neutropenia.
Mechanism of action
PK/PD interactions.
Clinical management
Monitor counts and AEs; adjust doses.
Drug reference
References
Frequently asked questions
Can I take clozapine with valproate?
The interaction is rated: Major. ↑ clozapine levels/sedation; rare neutropenia.
How serious is the interaction between clozapine and valproate?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between clozapine and valproate managed?
Monitor counts and AEs; adjust doses.
Why do clozapine and valproate interact?
PK/PD interactions.
Full monographs, dosing and an interaction checker in the MediHelp app
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