Drug interactions
lamotrigine + valproate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ lamotrigine → SJS/TEN risk.
Mechanism of action
Inhibits LTG glucuronidation.
Clinical management
Use reduced LTG dosing; monitor for rash.
Drug reference
References
Frequently asked questions
Can I take lamotrigine with valproate?
The interaction is rated: Major. ↑ lamotrigine → SJS/TEN risk.
How serious is the interaction between lamotrigine and valproate?
The interaction is rated: Major. Evidence level: High.
How is the interaction between lamotrigine and valproate managed?
Use reduced LTG dosing; monitor for rash.
Why do lamotrigine and valproate interact?
Inhibits LTG glucuronidation.
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