Drug interactions
aceclofenac + glimepiride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Aceclofenac is metabolized partly by CYP2C9, and NSAIDs may potentiate the hypoglycemic action of sulfonylureas. Clinically important hypoglycemia is uncommon but possible.
Mechanism of action
Possible competition for CYP2C9 metabolism and protein binding; the mechanism is not firmly established.
Clinical management
Monitor blood glucose when aceclofenac is started or stopped. Reduce the glimepiride dose if hypoglycemia occurs.
Drug reference
Frequently asked questions
Can I take aceclofenac with glimepiride?
The interaction is rated: Moderate. Aceclofenac is metabolized partly by CYP2C9, and NSAIDs may potentiate the hypoglycemic action of sulfonylureas. Clinically important hypoglycemia is uncommon but possible.
How serious is the interaction between aceclofenac and glimepiride?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aceclofenac and glimepiride managed?
Monitor blood glucose when aceclofenac is started or stopped. Reduce the glimepiride dose if hypoglycemia occurs.
Why do aceclofenac and glimepiride interact?
Possible competition for CYP2C9 metabolism and protein binding; the mechanism is not firmly established.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.