Drug reference
glimepiride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Insulin secretagogues)
Mechanism of action
Initial effect to increase insulin secretion from beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity
Common side effects
- Asthenia
- Dizziness
- Headache
- Nausea
- Hypoglycemia
- Allergic skin reactions
Known interactions (224)
- fluconazole + glimepiride Major
- glimepiride + insulin degludec-liraglutide Major
- glimepiride + insulin glargine-lixisenatide Major
- glimepiride + sulfamethoxazole Major
- aceclofenac + glimepiride Moderate
- acemetacin + glimepiride Moderate
- acetylsalicylic acid + glimepiride Moderate
- albiglutide + glimepiride Moderate
- alogliptin + glimepiride Moderate
- alogliptin-metformin + glimepiride Moderate
- alogliptin-pioglitazone + glimepiride Moderate
- aminolevulinic acid + glimepiride Moderate
- Amlodipine + glimepiride Moderate
- amlodipine-perindopril + glimepiride Moderate
- apalutamide + glimepiride Moderate
- aripiprazole + glimepiride Moderate
- asenapine + glimepiride Moderate
- aspirin / citric acid / sodium bicarbonate + glimepiride Moderate
- aspirin rectal + glimepiride Moderate
- atenolol-chlorthalidone + glimepiride Moderate
- benazepril + glimepiride Moderate
- bexarotene + glimepiride Moderate
- bitter melon + glimepiride Moderate
- canagliflozin + glimepiride Moderate
- canagliflozin-metformin + glimepiride Moderate
- candesartan-hydrochlorothiazide + glimepiride Moderate
- Captopril + glimepiride Moderate
- captopril-hydrochlorothiazide + glimepiride Moderate
- celecoxib + glimepiride Moderate
- chloramphenicol + glimepiride Moderate
- chlorthalidone + glimepiride Moderate
- choline magnesium trisalicylate + glimepiride Moderate
- ciprofibrate + glimepiride Moderate
- ciprofloxacin + glimepiride Moderate
- clarithromycin + glimepiride Moderate
- clonidine + glimepiride Moderate
- clozapine + glimepiride Moderate
- colesevelam + glimepiride Moderate
- cyclosporin + glimepiride Moderate
- dapagliflozin + glimepiride Moderate
- dapagliflozin-metformin + glimepiride Moderate
- deflazacort + glimepiride Moderate
- dexamethasone + glimepiride Moderate
- diclofenac + glimepiride Moderate
- diflunisal + glimepiride Moderate
- disopyramide + glimepiride Moderate
- dulaglutide + glimepiride Moderate
- empagliflozin + glimepiride Moderate
- empagliflozin-linagliptin + glimepiride Moderate
- empagliflozin-metformin + glimepiride Moderate
Related conditions
Frequently asked questions
What drug class is glimepiride?
glimepiride belongs to: Endocrine.
How does glimepiride work?
Initial effect to increase insulin secretion from beta cells; may also decrease rate of hepatic glucose production and increase insulin receptor sensitivity
What are the common side effects of glimepiride?
Asthenia, Dizziness, Headache, Nausea, Hypoglycemia, Allergic skin reactions
Which drugs interact with glimepiride?
fluconazole, insulin degludec-liraglutide, insulin glargine-lixisenatide, sulfamethoxazole, aceclofenac, acemetacin, acetylsalicylic acid, albiglutide, alogliptin, alogliptin-metformin, alogliptin-pioglitazone, aminolevulinic acid, Amlodipine, amlodipine-perindopril, apalutamide
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