Drug interactions
alogliptin + glimepiride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Alogliptin combined with a sulfonylurea increases the risk of hypoglycemia compared with the sulfonylurea alone. Labeling advises considering a lower sulfonylurea dose.
Mechanism of action
Additive pharmacodynamic effect: DPP-4 inhibition enhances glucose-dependent insulin secretion on top of sulfonylurea-induced release.
Clinical management
Consider lowering the glimepiride dose when alogliptin is added. Monitor blood glucose and counsel on hypoglycemia.
Drug reference
Frequently asked questions
Can I take alogliptin with glimepiride?
The interaction is rated: Moderate. Alogliptin combined with a sulfonylurea increases the risk of hypoglycemia compared with the sulfonylurea alone. Labeling advises considering a lower sulfonylurea dose.
How serious is the interaction between alogliptin and glimepiride?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between alogliptin and glimepiride managed?
Consider lowering the glimepiride dose when alogliptin is added. Monitor blood glucose and counsel on hypoglycemia.
Why do alogliptin and glimepiride interact?
Additive pharmacodynamic effect: DPP-4 inhibition enhances glucose-dependent insulin secretion on top of sulfonylurea-induced release.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.