Drug interactions
aminolevulinic acid + amlodipine-olmesartan-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity used for imaging during surgery. Together they may increase the risk of phototoxic skin reactions.
Mechanism of action
Additive phototoxicity from two photosensitizing agents.
Clinical management
Avoid other photosensitizing drugs during the perioperative period of aminolevulinic acid use, and counsel on strict sun and bright light protection. Hold hydrochlorothiazide temporarily if clinically appropriate.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with amlodipine-olmesartan-hydrochlorothiazide?
The interaction is rated: Moderate. Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity used for imaging during surgery. Together they may increase the risk of phototoxic skin reactions.
How serious is the interaction between aminolevulinic acid and amlodipine-olmesartan-hydrochlorothiazide?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and amlodipine-olmesartan-hydrochlorothiazide managed?
Avoid other photosensitizing drugs during the perioperative period of aminolevulinic acid use, and counsel on strict sun and bright light protection. Hold hydrochlorothiazide temporarily if clinically appropriate.
Why do aminolevulinic acid and amlodipine-olmesartan-hydrochlorothiazide interact?
Additive phototoxicity from two photosensitizing agents.
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