Drug reference
amlodipine-olmesartan-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Olmesartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors. Amlodipine: Dihydropyridine calcium channel blocker; inhibits extracellular Ca ions across the membranes of myocardial cells and vascular smooth muscle cells. HCT: Inhibits Na reabsorption in distal renal tubules resulting in increased Na and water excretion
Common side effects
- Dizziness
- Headache
- Fatigue
- Nausea
- Muscle spasms
- Peripheral edema
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to any drug component or sulfonamide-derived drug Anuria Concomitant use with aliskiren in patients with diabetes mellitus Pregnancy (2nd and 3rd trimesters): significant risk of fetal/neonatal morbidity and mortality
Known interactions (2)
Related conditions
Frequently asked questions
What drug class is amlodipine-olmesartan-hydrochlorothiazide?
amlodipine-olmesartan-hydrochlorothiazide belongs to: Cardiovascular.
How does amlodipine-olmesartan-hydrochlorothiazide work?
Olmesartan: Blocks binding of angiotensin II to type 1 angiotensin II receptors. Amlodipine: Dihydropyridine calcium channel blocker; inhibits extracellular Ca ions across the membranes of myocardial cells and vascular smooth muscle cells. HCT: Inhibits Na reabsorption in distal renal tubules resulting in increased Na and water excretion
What are the common side effects of amlodipine-olmesartan-hydrochlorothiazide?
Dizziness, Headache, Fatigue, Nausea, Muscle spasms, Peripheral edema
Which drugs interact with amlodipine-olmesartan-hydrochlorothiazide?
dantrolene, isocarboxazid
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.