Drug interactions
aminolevulinic acid + captopril-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a photosensitizing drug and may add to the phototoxic potential of oral aminolevulinic acid, which causes protoporphyrin accumulation in tissues. Patients may develop exaggerated skin reactions to light exposure in the perioperative period.
Mechanism of action
Additive photosensitizing effects through pharmacodynamic synergism.
Clinical management
Avoid giving other photosensitizing drugs around the time of oral aminolevulinic acid administration, and counsel the patient on strict light and sun protection for the period stated in labeling.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with captopril-hydrochlorothiazide?
The interaction is rated: Moderate. Hydrochlorothiazide is a photosensitizing drug and may add to the phototoxic potential of oral aminolevulinic acid, which causes protoporphyrin accumulation in tissues. Patients may develop exaggerated skin reactions to light exposure in the perioperative period.
How serious is the interaction between aminolevulinic acid and captopril-hydrochlorothiazide?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and captopril-hydrochlorothiazide managed?
Avoid giving other photosensitizing drugs around the time of oral aminolevulinic acid administration, and counsel the patient on strict light and sun protection for the period stated in labeling.
Why do aminolevulinic acid and captopril-hydrochlorothiazide interact?
Additive photosensitizing effects through pharmacodynamic synergism.
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