Drug reference
captopril-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Captopril/hydrochlorothiazide is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, captopril, and a thiazide diuretic, hydrochlorothiazide
Common side effects
- Angioedema
- Anorexia
- Chest pain
- Cough
- Hypersensitivity reactions
- Dysgeusia
Boxed warnings
- Captopril: Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to either component or sulfonamides History of hereditary or idiopathic angioedema Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/val…
Related conditions
Frequently asked questions
What drug class is captopril-hydrochlorothiazide?
captopril-hydrochlorothiazide belongs to: Cardiovascular.
How does captopril-hydrochlorothiazide work?
Captopril/hydrochlorothiazide is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, captopril, and a thiazide diuretic, hydrochlorothiazide
What are the common side effects of captopril-hydrochlorothiazide?
Angioedema, Anorexia, Chest pain, Cough, Hypersensitivity reactions, Dysgeusia
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