Drug interactions
aminolevulinic acid + chlorpromazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes photosensitivity through protoporphyrin accumulation, and chlorpromazine is also a known photosensitizing agent. Together they may increase the risk of phototoxic skin reactions.
Mechanism of action
Additive phototoxicity from two photosensitizing drugs.
Clinical management
Avoid giving chlorpromazine for the 24 hours around perioperative aminolevulinic acid use if feasible. Counsel the patient on strict sun and bright light protection.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with chlorpromazine?
The interaction is rated: Moderate. Oral aminolevulinic acid causes photosensitivity through protoporphyrin accumulation, and chlorpromazine is also a known photosensitizing agent. Together they may increase the risk of phototoxic skin reactions.
How serious is the interaction between aminolevulinic acid and chlorpromazine?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between aminolevulinic acid and chlorpromazine managed?
Avoid giving chlorpromazine for the 24 hours around perioperative aminolevulinic acid use if feasible. Counsel the patient on strict sun and bright light protection.
Why do aminolevulinic acid and chlorpromazine interact?
Additive phototoxicity from two photosensitizing drugs.
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