Drug reference
chlorpromazine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Anti Psychotic)
Mechanism of action
Phenothiazine; antagonizes dopamine D2 receptors in brain; depresses release of hypothalamic and hypophyseal hormones; may also depress reticular activating system
Common side effects
- Anticholinergic effects
- Erectile dysfunction
- Sedation
- Akathisia
- Weight gain
- Dystonia
- Muscle stiffness
Known interactions (13)
- chlorpromazine + pimozide Contraindicated
- amisulpride + chlorpromazine Major
- cabergoline + chlorpromazine Major
- chlorpromazine + indapamide Major
- chlorpromazine + pramipexole Major
- chlorpromazine + quinidine Major
- chlorpromazine + ropinirole Major
- chlorpromazine + sotalol Major
- carvedilol + chlorpromazine Moderate
- chlorpromazine + dopamine Moderate
- chlorpromazine + methyldopa Moderate
- chlorpromazine + metoprolol Moderate
- chlorpromazine + propranolol Moderate
Related conditions
Frequently asked questions
What drug class is chlorpromazine?
chlorpromazine belongs to: Central Nervous System.
How does chlorpromazine work?
Phenothiazine; antagonizes dopamine D2 receptors in brain; depresses release of hypothalamic and hypophyseal hormones; may also depress reticular activating system
What are the common side effects of chlorpromazine?
Anticholinergic effects, Erectile dysfunction, Sedation, Akathisia, Weight gain, Dystonia, Muscle stiffness
Which drugs interact with chlorpromazine?
pimozide, amisulpride, cabergoline, indapamide, pramipexole, quinidine, ropinirole, sotalol, carvedilol, dopamine, methyldopa, metoprolol, propranolol
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