Drug interactions
aminolevulinic acid + chlorthalidone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Chlorthalidone, a thiazide-like diuretic, may cause photosensitivity, and oral aminolevulinic acid causes transient skin photosensitivity. Combined use may increase the chance of phototoxic reactions.
Mechanism of action
Additive photosensitizing effects through pharmacodynamic synergism.
Clinical management
Avoid other photosensitizing drugs during the perioperative period of oral aminolevulinic acid and instruct the patient to avoid sunlight and bright light exposure. Consider temporarily holding chlorthalidone if clinically acceptable.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with chlorthalidone?
The interaction is rated: Moderate. Chlorthalidone, a thiazide-like diuretic, may cause photosensitivity, and oral aminolevulinic acid causes transient skin photosensitivity. Combined use may increase the chance of phototoxic reactions.
How serious is the interaction between aminolevulinic acid and chlorthalidone?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and chlorthalidone managed?
Avoid other photosensitizing drugs during the perioperative period of oral aminolevulinic acid and instruct the patient to avoid sunlight and bright light exposure. Consider temporarily holding chlorthalidone if clinically acceptable.
Why do aminolevulinic acid and chlorthalidone interact?
Additive photosensitizing effects through pharmacodynamic synergism.
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