Drug interactions
aminolevulinic acid + diclofenac
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes skin photosensitivity. Diclofenac has photosensitising potential, so the combination might add to the risk of phototoxic reactions.
Mechanism of action
Additive phototoxic effects from two photosensitising agents.
Clinical management
Avoid diclofenac and other photosensitisers during the perioperative period after aminolevulinic acid, using an alternative analgesic if needed. Reinforce strict light protection.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with diclofenac?
The interaction is rated: Moderate. Oral aminolevulinic acid causes skin photosensitivity. Diclofenac has photosensitising potential, so the combination might add to the risk of phototoxic reactions.
How serious is the interaction between aminolevulinic acid and diclofenac?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and diclofenac managed?
Avoid diclofenac and other photosensitisers during the perioperative period after aminolevulinic acid, using an alternative analgesic if needed. Reinforce strict light protection.
Why do aminolevulinic acid and diclofenac interact?
Additive phototoxic effects from two photosensitising agents.
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