Drug reference
diclofenac
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.
Common side effects
- Constipation
- Edema
- Nausea
- GI ulcers (gastric/duodenal)
- Abdominal pain
Contraindications
- In the setting of coronary artery bypass graft (CABG) surgery
- Zipsor capsules are contraindicated in patients with history of hypersensitivity to bovine protein
- Hypersensitivity to ASA, NSAIDs, or components of the formulation
- Flector patch: Use on non-intact or damaged skin resulting from any etiology, including exudative dermatitis, eczema, infection lesions, burns or wounds
- CABG perioperative period
Known interactions (6)
- Celecoxib + diclofenac Major
- diclofenac + Escitalopram Major
- diclofenac + ibuprofen Major
- diclofenac + Piroxicam Major
- dexamethasone + diclofenac Moderate
- diclofenac + gentamicin Moderate
Related conditions
Frequently asked questions
What drug class is diclofenac?
diclofenac belongs to: Musculoskeletal.
How does diclofenac work?
Inhibits cyclooxygenase (COX)-1 and COX-2, thereby inhibiting prostaglandin synthesis. May also inhibit neutrophil aggregation/activation, inhibit chemotaxis, decrease proinflammatory cytokine level, and alter lymphocyte activity.
What are the common side effects of diclofenac?
Constipation, Edema, Nausea, GI ulcers (gastric/duodenal), Abdominal pain
Which drugs interact with diclofenac?
Celecoxib, Escitalopram, ibuprofen, Piroxicam, dexamethasone, gentamicin
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