Drug interactions
aminolevulinic acid + doxycycline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes photosensitization through protoporphyrin accumulation, and doxycycline is also phototoxic. Together they may increase the risk of severe sunburn-like skin reactions after light exposure.
Mechanism of action
Additive phototoxicity from porphyrin-induced photosensitization and doxycycline photoreactivity.
Clinical management
Avoid doxycycline around the perioperative period of aminolevulinic acid use, and for about 24 hours as labeled, or choose a non-phototoxic antibiotic. Advise strict protection from sunlight and bright indoor light.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with doxycycline?
The interaction is rated: Major. Oral aminolevulinic acid causes photosensitization through protoporphyrin accumulation, and doxycycline is also phototoxic. Together they may increase the risk of severe sunburn-like skin reactions after light exposure.
How serious is the interaction between aminolevulinic acid and doxycycline?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between aminolevulinic acid and doxycycline managed?
Avoid doxycycline around the perioperative period of aminolevulinic acid use, and for about 24 hours as labeled, or choose a non-phototoxic antibiotic. Advise strict protection from sunlight and bright indoor light.
Why do aminolevulinic acid and doxycycline interact?
Additive phototoxicity from porphyrin-induced photosensitization and doxycycline photoreactivity.
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