Drug interactions
aminolevulinic acid + fosinopril-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a recognized photosensitizer, and oral aminolevulinic acid causes photosensitivity of the skin and eyes. Using both increases the risk of phototoxic skin reactions such as severe sunburn.
Mechanism of action
Additive phototoxicity from protoporphyrin accumulation and thiazide photosensitization.
Clinical management
Strictly avoid sunlight and bright indoor light as directed in the labeling for aminolevulinic acid; consider withholding hydrochlorothiazide in the perioperative period if feasible.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with fosinopril-hydrochlorothiazide?
The interaction is rated: Moderate. Hydrochlorothiazide is a recognized photosensitizer, and oral aminolevulinic acid causes photosensitivity of the skin and eyes. Using both increases the risk of phototoxic skin reactions such as severe sunburn.
How serious is the interaction between aminolevulinic acid and fosinopril-hydrochlorothiazide?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between aminolevulinic acid and fosinopril-hydrochlorothiazide managed?
Strictly avoid sunlight and bright indoor light as directed in the labeling for aminolevulinic acid; consider withholding hydrochlorothiazide in the perioperative period if feasible.
Why do aminolevulinic acid and fosinopril-hydrochlorothiazide interact?
Additive phototoxicity from protoporphyrin accumulation and thiazide photosensitization.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.