Drug reference
fosinopril-hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Competitively inhibits angiotensin-converting enzymes, resulting in decreased plasma angiotensin II concentrations; BP may be reduced in part through decreased vasoconstriction, increased renin activity, and decreased aldosterone secretion; increases renal blood flow
Common side effects
- Dizziness
- Headache
- Fatigue
- Hyperkalemia
- Cough
- Orthostatic hypotension
- Diarrhea
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to ACE inhibitors, thiazides or sulfonamides History of hereditary or angioedema associated with previous ACE inhibitor treatment Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors with…
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is fosinopril-hydrochlorothiazide?
fosinopril-hydrochlorothiazide belongs to: Cardiovascular.
How does fosinopril-hydrochlorothiazide work?
Competitively inhibits angiotensin-converting enzymes, resulting in decreased plasma angiotensin II concentrations; BP may be reduced in part through decreased vasoconstriction, increased renin activity, and decreased aldosterone secretion; increases renal blood flow
What are the common side effects of fosinopril-hydrochlorothiazide?
Dizziness, Headache, Fatigue, Hyperkalemia, Cough, Orthostatic hypotension, Diarrhea
Which drugs interact with fosinopril-hydrochlorothiazide?
isocarboxazid
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.