Drug interactions
aminolevulinic acid + hydrochlorothiazide-lisinopril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity through accumulation of protoporphyrin IX. Using them together may increase the risk of phototoxic skin reactions after exposure to light.
Mechanism of action
Additive photosensitizing effects of the two agents.
Clinical management
Advise strict protection from sunlight and bright indoor light for the period specified in the aminolevulinic acid labeling. Avoid giving other photosensitizing drugs in the perioperative window where feasible.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with hydrochlorothiazide-lisinopril?
The interaction is rated: Moderate. Hydrochlorothiazide is a photosensitizing drug, and oral aminolevulinic acid causes photosensitivity through accumulation of protoporphyrin IX. Using them together may increase the risk of phototoxic skin reactions after exposure to light.
How serious is the interaction between aminolevulinic acid and hydrochlorothiazide-lisinopril?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and hydrochlorothiazide-lisinopril managed?
Advise strict protection from sunlight and bright indoor light for the period specified in the aminolevulinic acid labeling. Avoid giving other photosensitizing drugs in the perioperative window where feasible.
Why do aminolevulinic acid and hydrochlorothiazide-lisinopril interact?
Additive photosensitizing effects of the two agents.
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