Drug reference
hydrochlorothiazide-lisinopril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Combination(CVS))
Mechanism of action
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water
Common side effects
- Anorexia
- Dizziness
- Headache
- Hyperkalemia
- Hypotension
- Cough
- Diarrhea
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to ACE inhibitors, thiazides, or sulfonamides ACE-inhibitor induced angioedema, hereditary or idiopathic angioedema Coadministration of ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan Anuria or renal stenosis Coadministration with aliskiren in p…
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is hydrochlorothiazide-lisinopril?
hydrochlorothiazide-lisinopril belongs to: Cardiovascular.
How does hydrochlorothiazide-lisinopril work?
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competitively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water
What are the common side effects of hydrochlorothiazide-lisinopril?
Anorexia, Dizziness, Headache, Hyperkalemia, Hypotension, Cough, Diarrhea
Which drugs interact with hydrochlorothiazide-lisinopril?
isocarboxazid
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