Drug interactions
aminolevulinic acid + hydrochlorothiazide-losartan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide is a recognised photosensitising drug, and oral aminolevulinic acid used for visualisation in glioma surgery causes photosensitivity. Combined use may increase the risk of phototoxic skin reactions after exposure to light.
Mechanism of action
Additive photosensitisation from hydrochlorothiazide and protoporphyrin accumulation from aminolevulinic acid.
Clinical management
Avoid other phototoxic drugs during the perioperative period as advised in the aminolevulinic acid label, and counsel the patient to avoid strong light and sun exposure for the recommended period.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with hydrochlorothiazide-losartan?
The interaction is rated: Moderate. Hydrochlorothiazide is a recognised photosensitising drug, and oral aminolevulinic acid used for visualisation in glioma surgery causes photosensitivity. Combined use may increase the risk of phototoxic skin reactions after exposure to light.
How serious is the interaction between aminolevulinic acid and hydrochlorothiazide-losartan?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between aminolevulinic acid and hydrochlorothiazide-losartan managed?
Avoid other phototoxic drugs during the perioperative period as advised in the aminolevulinic acid label, and counsel the patient to avoid strong light and sun exposure for the recommended period.
Why do aminolevulinic acid and hydrochlorothiazide-losartan interact?
Additive photosensitisation from hydrochlorothiazide and protoporphyrin accumulation from aminolevulinic acid.
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