Drug interactions
aminolevulinic acid + hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Hydrochlorothiazide can cause photosensitivity, and oral aminolevulinic acid used for imaging causes protoporphyrin IX accumulation and skin photosensitivity. Together the risk of phototoxic skin reactions after sun or bright light exposure may be increased.
Mechanism of action
Additive photosensitizing effects through pharmacodynamic synergism.
Clinical management
Avoid giving other photosensitizing drugs around the perioperative period of oral aminolevulinic acid, and advise strict protection from sunlight and bright indoor light. Consider holding hydrochlorothiazide temporarily if clinically acceptable.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with hydrochlorothiazide?
The interaction is rated: Moderate. Hydrochlorothiazide can cause photosensitivity, and oral aminolevulinic acid used for imaging causes protoporphyrin IX accumulation and skin photosensitivity. Together the risk of phototoxic skin reactions after sun or bright light exposure may be increased.
How serious is the interaction between aminolevulinic acid and hydrochlorothiazide?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and hydrochlorothiazide managed?
Avoid giving other photosensitizing drugs around the perioperative period of oral aminolevulinic acid, and advise strict protection from sunlight and bright indoor light. Consider holding hydrochlorothiazide temporarily if clinically acceptable.
Why do aminolevulinic acid and hydrochlorothiazide interact?
Additive photosensitizing effects through pharmacodynamic synergism.
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