Drug reference
hydrochlorothiazide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Diuretics)
Mechanism of action
Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
Common side effects
- Anorexia
- Dizziness
- Headache
- Fatigue
- Disorder of hematopoietic structure
- Confusion
- Epigastric distress
Known interactions (5)
- dofetilide + hydrochlorothiazide Contraindicated
- hydrochlorothiazide + lithium Major
- Betamethasone + hydrochlorothiazide Moderate
- Enalapril + hydrochlorothiazide Moderate
- hydrochlorothiazide + isocarboxazid Moderate
Related conditions
Frequently asked questions
What drug class is hydrochlorothiazide?
hydrochlorothiazide belongs to: Cardiovascular.
How does hydrochlorothiazide work?
Thiazide diuretic; inhibits sodium reabsorption in distal renal tubules, resulting in increased excretion of water and of sodium, potassium, and hydrogen ions
What are the common side effects of hydrochlorothiazide?
Anorexia, Dizziness, Headache, Fatigue, Disorder of hematopoietic structure, Confusion, Epigastric distress
Which drugs interact with hydrochlorothiazide?
dofetilide, lithium, Betamethasone, Enalapril, isocarboxazid
Full monographs, dosing and an interaction checker in the MediHelp app
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