Drug interactions
aminolevulinic acid + indomethacin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes skin photosensitivity from protoporphyrin IX accumulation. Indomethacin has photosensitising potential, though weak, so additive phototoxicity is possible.
Mechanism of action
Theoretical additive phototoxicity from two photosensitising agents.
Clinical management
Avoid other photosensitising drugs during the perioperative period after aminolevulinic acid and use an alternative analgesic if feasible. Ensure strict light protection.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with indomethacin?
The interaction is rated: Moderate. Oral aminolevulinic acid causes skin photosensitivity from protoporphyrin IX accumulation. Indomethacin has photosensitising potential, though weak, so additive phototoxicity is possible.
How serious is the interaction between aminolevulinic acid and indomethacin?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and indomethacin managed?
Avoid other photosensitising drugs during the perioperative period after aminolevulinic acid and use an alternative analgesic if feasible. Ensure strict light protection.
Why do aminolevulinic acid and indomethacin interact?
Theoretical additive phototoxicity from two photosensitising agents.
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