Drug reference
indomethacin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity.
Common side effects
- Epigastric pain
- Transient renal insufficiency
- Headache
- Jaundice
- Elevated liver function test values
Contraindications
- Absolute Contraindications History of hypersensitivity (anaphylactic or serious skin reactions) History of urticaria, asthma, or allergic type reactions with aspirin Preoperative pain associated with CABG surgery History of proctitis or recent rectal bleeding (suppositories)
- Relative Contraindications Bleeding disorder Duodenal/gastric/peptic ulcer Stomatitis Ulcerative colitis Upper GI disease Late pregnancy (may cause premature closure of ductus arteriosus)
Known interactions (1)
- indomethacin + ketorolac Contraindicated
Related conditions
Frequently asked questions
What drug class is indomethacin?
indomethacin belongs to: Musculoskeletal.
How does indomethacin work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclo-oxygenase (COX) isoenzymes, COX-1 and COX-2. May inhibit chemotaxis, alter lymphocyte activity, decrease proinflammatory cytokine activity, and inhibit neutrophil aggregation; these effects may contribute to anti-inflammatory activity.
What are the common side effects of indomethacin?
Epigastric pain, Transient renal insufficiency, Headache, Jaundice, Elevated liver function test values
Which drugs interact with indomethacin?
ketorolac
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