Drug interactions
aminolevulinic acid + ketoprofen
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes photosensitivity, and ketoprofen is a recognized photosensitizer that can add to the risk of skin phototoxic reactions.
Mechanism of action
Additive photosensitization from protoporphyrin accumulation and ketoprofen's phototoxic potential.
Clinical management
Avoid ketoprofen, particularly topical forms, during the photosensitivity period in the aminolevulinic acid labeling, and counsel strict light protection. Use paracetamol as an alternative analgesic.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with ketoprofen?
The interaction is rated: Moderate. Oral aminolevulinic acid causes photosensitivity, and ketoprofen is a recognized photosensitizer that can add to the risk of skin phototoxic reactions.
How serious is the interaction between aminolevulinic acid and ketoprofen?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and ketoprofen managed?
Avoid ketoprofen, particularly topical forms, during the photosensitivity period in the aminolevulinic acid labeling, and counsel strict light protection. Use paracetamol as an alternative analgesic.
Why do aminolevulinic acid and ketoprofen interact?
Additive photosensitization from protoporphyrin accumulation and ketoprofen's phototoxic potential.
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