Drug interactions
aminolevulinic acid + mefenamic acid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Oral aminolevulinic acid causes protoporphyrin accumulation and transient photosensitivity, and labeling advises avoiding other phototoxic agents in the perioperative period. Mefenamic acid has some photosensitizing potential, so additive skin phototoxicity is theoretically possible.
Mechanism of action
Additive photosensitization, with protoporphyrin IX accumulation from aminolevulinic acid plus the photosensitizing potential of the NSAID.
Clinical management
Avoid giving mefenamic acid for about 24 hours around oral aminolevulinic acid use and use another analgesic if feasible. Advise strict protection of skin and eyes from bright light during that period.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with mefenamic acid?
The interaction is rated: Moderate. Oral aminolevulinic acid causes protoporphyrin accumulation and transient photosensitivity, and labeling advises avoiding other phototoxic agents in the perioperative period. Mefenamic acid has some photosensitizing potential, so additive skin phototoxicity is theoretically possible.
How serious is the interaction between aminolevulinic acid and mefenamic acid?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and mefenamic acid managed?
Avoid giving mefenamic acid for about 24 hours around oral aminolevulinic acid use and use another analgesic if feasible. Advise strict protection of skin and eyes from bright light during that period.
Why do aminolevulinic acid and mefenamic acid interact?
Additive photosensitization, with protoporphyrin IX accumulation from aminolevulinic acid plus the photosensitizing potential of the NSAID.
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