Drug reference
mefenamic acid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Musculoskeletal (NSAIDs)
Mechanism of action
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2). May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity
Common side effects
- Anorexia
- Nausea
- Gastritis
- Upper GI ulcers, gross bleeding/perforation
- Abdominal pain
- Diarrhea
Contraindications
- Hypersensitivity, ASA allergy, history of aspirin triad, GI tract ulcer/inflammation, CABG, renal dz, late pregnancy (may cause premature closure of ductus arteriosus)
Related conditions
Frequently asked questions
What drug class is mefenamic acid?
mefenamic acid belongs to: Musculoskeletal.
How does mefenamic acid work?
Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2). May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity
What are the common side effects of mefenamic acid?
Anorexia, Nausea, Gastritis, Upper GI ulcers, gross bleeding/perforation, Abdominal pain, Diarrhea
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