Drug interactions
aminolevulinic acid + metolazone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Metolazone may cause photosensitivity, and oral aminolevulinic acid causes transient skin photosensitivity. Combined use may increase phototoxic reactions.
Mechanism of action
Additive photosensitizing effects through pharmacodynamic synergism.
Clinical management
Avoid other photosensitizers around the perioperative period of oral aminolevulinic acid and instruct strict avoidance of sunlight and bright light. Consider temporarily holding metolazone if feasible.
Drug reference
Frequently asked questions
Can I take aminolevulinic acid with metolazone?
The interaction is rated: Moderate. Metolazone may cause photosensitivity, and oral aminolevulinic acid causes transient skin photosensitivity. Combined use may increase phototoxic reactions.
How serious is the interaction between aminolevulinic acid and metolazone?
The interaction is rated: Moderate. Evidence level: Low.
How is the interaction between aminolevulinic acid and metolazone managed?
Avoid other photosensitizers around the perioperative period of oral aminolevulinic acid and instruct strict avoidance of sunlight and bright light. Consider temporarily holding metolazone if feasible.
Why do aminolevulinic acid and metolazone interact?
Additive photosensitizing effects through pharmacodynamic synergism.
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