Drug interactions
Amlodipine + Furosemide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive blood pressure lowering with risk of symptomatic hypotension, dizziness, or syncope, especially during initiation or dose escalation.
Mechanism of action
Pharmacodynamic: vasodilation from amlodipine plus diuresis/volume depletion from furosemide.
Clinical management
Start at lower doses when combined; monitor seated/standing BP, renal function, and electrolytes; counsel on orthostatic precautions.
Drug reference
References
- Amlodipine: Drug Interactions — Lexicomp
- Furosemide: Drug Interactions — Lexicomp
Frequently asked questions
Can I take Amlodipine with Furosemide?
The interaction is rated: Moderate. Additive blood pressure lowering with risk of symptomatic hypotension, dizziness, or syncope, especially during initiation or dose escalation.
How serious is the interaction between Amlodipine and Furosemide?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Amlodipine and Furosemide managed?
Start at lower doses when combined; monitor seated/standing BP, renal function, and electrolytes; counsel on orthostatic precautions.
Why do Amlodipine and Furosemide interact?
Pharmacodynamic: vasodilation from amlodipine plus diuresis/volume depletion from furosemide.
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