Drug interactions
amoxicillin/clavulanate + gentamicin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Beta-lactams can inactivate aminoglycosides if mixed; in vivo, especially with renal impairment, may reduce aminoglycoside activity/levels.
Mechanism of action
Chemical inactivation of aminoglycosides by beta-lactams (in vitro/in vivo) and incompatibility when co-mixed in IV solutions.
Clinical management
Do not mix in same IV solution or Y-site; administer separately with line flush. Monitor gentamicin peak/trough and renal function; adjust dose as needed.
Drug reference
References
- Gentamicin Injection Prescribing Information — Incompatibilities/Drug Interactions — FDA Label
- Aminoglycosides—Penicillins: Inactivation/Compatibility — Lexicomp
Frequently asked questions
Can I take amoxicillin/clavulanate with gentamicin?
The interaction is rated: Moderate. Beta-lactams can inactivate aminoglycosides if mixed; in vivo, especially with renal impairment, may reduce aminoglycoside activity/levels.
How serious is the interaction between amoxicillin/clavulanate and gentamicin?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between amoxicillin/clavulanate and gentamicin managed?
Do not mix in same IV solution or Y-site; administer separately with line flush. Monitor gentamicin peak/trough and renal function; adjust dose as needed.
Why do amoxicillin/clavulanate and gentamicin interact?
Chemical inactivation of aminoglycosides by beta-lactams (in vitro/in vivo) and incompatibility when co-mixed in IV solutions.
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