Drug interactions
apixaban + rifampin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ apixaban → thrombosis risk.
Mechanism of action
CYP3A/P-gp induction.
Clinical management
Avoid combination.
Drug reference
References
Frequently asked questions
Can I take apixaban with rifampin?
The interaction is rated: Major. ↓ apixaban → thrombosis risk.
How serious is the interaction between apixaban and rifampin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between apixaban and rifampin managed?
Avoid combination.
Why do apixaban and rifampin interact?
CYP3A/P-gp induction.
Full monographs, dosing and an interaction checker in the MediHelp app
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