Drug reference
apixaban
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Anti Thrombotics)
Mechanism of action
Factor Xa inhibitor that inhibits platelet activation by and reversibly blocking the active site of factor Xa without requiring a cofactor(eg, antithrombin III) for activity Inhibits free and clot-bound factor Xa, and prothrombinase activity; no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin
Common side effects
- Bleeding
- Thrombocytopenia
- Hypotension
- Syncope
Known interactions (11)
- apixaban + mifepristone Contraindicated
- apixaban + carbamazepine Major
- apixaban + fondaparinux Major
- apixaban + ketoconazole Major
- apixaban + phenytoin Major
- apixaban + rifabutin Major
- apixaban + rifampin Major
- apixaban + secobarbital Major
- apixaban + dexamethasone Moderate
- apixaban + dexamethasone-neomycin-polymyxin Minor
- apixaban + dexamethasone-tobramycin Minor
Related conditions
Frequently asked questions
What drug class is apixaban?
apixaban belongs to: Cardiovascular.
How does apixaban work?
Factor Xa inhibitor that inhibits platelet activation by and reversibly blocking the active site of factor Xa without requiring a cofactor(eg, antithrombin III) for activity Inhibits free and clot-bound factor Xa, and prothrombinase activity; no direct effect on platelet aggregation, but indirectly inhibits platelet aggregation induced by thrombin
What are the common side effects of apixaban?
Bleeding, Thrombocytopenia, Hypotension, Syncope
Which drugs interact with apixaban?
mifepristone, carbamazepine, fondaparinux, ketoconazole, phenytoin, rifabutin, rifampin, secobarbital, dexamethasone, dexamethasone-neomycin-polymyxin, dexamethasone-tobramycin
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