Drug interactions
aspirin + eplerenone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
NSAIDs, including high-dose aspirin, may worsen renal function and blunt antihypertensive effects; with potassium-sparing agents like eplerenone, hyperkalemia risk increases.
Mechanism of action
NSAID-induced reduction in renal prostaglandins decreases renal perfusion and renin/aldosterone activity, predisposing to hyperkalemia and reduced BP control.
Clinical management
Avoid chronic/high-dose NSAIDs if possible; if required, use lowest dose and monitor BP, SCr/eGFR, and serum potassium at baseline and after changes.
Drug reference
References
- Inspra (eplerenone) Prescribing Information — FDA Label
- Lexicomp Drug Interactions (eplerenone; NSAIDs) — Lexicomp
Frequently asked questions
Can I take aspirin with eplerenone?
The interaction is rated: Moderate. NSAIDs, including high-dose aspirin, may worsen renal function and blunt antihypertensive effects; with potassium-sparing agents like eplerenone, hyperkalemia risk increases.
How serious is the interaction between aspirin and eplerenone?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between aspirin and eplerenone managed?
Avoid chronic/high-dose NSAIDs if possible; if required, use lowest dose and monitor BP, SCr/eGFR, and serum potassium at baseline and after changes.
Why do aspirin and eplerenone interact?
NSAID-induced reduction in renal prostaglandins decreases renal perfusion and renin/aldosterone activity, predisposing to hyperkalemia and reduced BP control.
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