Drug reference
eplerenone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Diuretics)
Mechanism of action
Selective aldosterone receptor antagonist; blocks aldosterone binding at the mineralocorticoid receptor
Common side effects
- Dizziness
- Hyperkalemia
- Fatigue/malaise
- Abdominal pain
- Diarrhea
Contraindications
- For all patients: Serum potassium >5.5 mEq/L at initiation Creatinine clearance ≤30 mL/min Concomitant use with strong CYP3A inhibitors For the treatment of hypertension: Type 2 diabetes with microalbuminuria Serum creatinine >2.0 mg/dL in males, >1.8 mg/dL in females Creatinine clearance <50 mL/mi…
- For all patients Serum potassium >5.5 mEq/L at initiation Creatinine clearance ≤30 mL/min Concomitant use with strong CYP3A inhibitors
- For the treatment of hypertension Type 2 diabetes with microalbuminuria Serum creatinine >2.0 mg/dL in males, >1.8 mg/dL in females Creatinine clearance <50 mL/min Concomitant use of potassium supplements or potassium-sparing diuretics
Known interactions (11)
- amiloride + eplerenone Contraindicated
- eplerenone + itraconazole Contraindicated
- eplerenone + ketoconazole Contraindicated
- eplerenone + spironolactone Contraindicated
- eplerenone + triamterene Contraindicated
- amiodarone + eplerenone Major
- drospirenone + eplerenone Major
- eplerenone + ethinyl estradiol-drospirenone Major
- eplerenone + mifepristone Major
- aspirin + eplerenone Moderate
- chloramphenicol + eplerenone Moderate
Related conditions
Frequently asked questions
What drug class is eplerenone?
eplerenone belongs to: Cardiovascular.
How does eplerenone work?
Selective aldosterone receptor antagonist; blocks aldosterone binding at the mineralocorticoid receptor
What are the common side effects of eplerenone?
Dizziness, Hyperkalemia, Fatigue/malaise, Abdominal pain, Diarrhea
Which drugs interact with eplerenone?
amiloride, itraconazole, ketoconazole, spironolactone, triamterene, amiodarone, drospirenone, ethinyl estradiol-drospirenone, mifepristone, aspirin, chloramphenicol
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