Drug interactions
aspirin + furosemide
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
NSAIDs can reduce the natriuretic/antihypertensive response to loop diuretics and increase risk of nephrotoxicity.
Mechanism of action
Prostaglandin inhibition leads to sodium and water retention and decreased renal blood flow; may also compete for tubular secretion, reducing furosemide effect.
Clinical management
Avoid NSAIDs when possible. Monitor weight/edema, urine output, blood pressure, and serum creatinine after NSAID initiation or dose changes; adjust diuretic as needed.
Drug reference
References
- Furosemide (Lasix) Prescribing Information — FDA Label
- Loop diuretics and NSAIDs: Interaction Monograph — Lexicomp
Frequently asked questions
Can I take aspirin with furosemide?
The interaction is rated: Moderate. NSAIDs can reduce the natriuretic/antihypertensive response to loop diuretics and increase risk of nephrotoxicity.
How serious is the interaction between aspirin and furosemide?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between aspirin and furosemide managed?
Avoid NSAIDs when possible. Monitor weight/edema, urine output, blood pressure, and serum creatinine after NSAID initiation or dose changes; adjust diuretic as needed.
Why do aspirin and furosemide interact?
Prostaglandin inhibition leads to sodium and water retention and decreased renal blood flow; may also compete for tubular secretion, reducing furosemide effect.
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