Drug interactions
aspirin + ramipril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Aspirin (NSAID) may attenuate the antihypertensive effect of ACE inhibitors and increase risk of renal impairment, especially at higher doses.
Mechanism of action
Pharmacodynamic: inhibition of vasodilatory renal prostaglandins by aspirin opposes ACE inhibitor effects on renal hemodynamics; may reduce natriuresis.
Clinical management
Use the lowest effective aspirin dose; monitor BP, serum creatinine, and potassium at baseline and after initiation or dose changes; avoid dehydration and additional nephrotoxins.
Drug reference
References
- Ramipril (Altace) Prescribing Information — FDA Label
- Lexicomp Interaction Monograph: ACE inhibitors + NSAIDs — Lexicomp
- UpToDate: NSAIDs and hypertension — UpToDate
Frequently asked questions
Can I take aspirin with ramipril?
The interaction is rated: Moderate. Aspirin (NSAID) may attenuate the antihypertensive effect of ACE inhibitors and increase risk of renal impairment, especially at higher doses.
How serious is the interaction between aspirin and ramipril?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between aspirin and ramipril managed?
Use the lowest effective aspirin dose; monitor BP, serum creatinine, and potassium at baseline and after initiation or dose changes; avoid dehydration and additional nephrotoxins.
Why do aspirin and ramipril interact?
Pharmacodynamic: inhibition of vasodilatory renal prostaglandins by aspirin opposes ACE inhibitor effects on renal hemodynamics; may reduce natriuresis.
Full monographs, dosing and an interaction checker in the MediHelp app
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