Drug reference
ramipril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (ACE Inhibitors)
Mechanism of action
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart
ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
Common side effects
- Dizziness
- Headache
- Nausea
- Hypotension
- Cough
- Angina pectoris
Boxed warnings
- Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death
Contraindications
- Hypersensitivity to drug or other ACE inhibitors Do not coadminister with aliskiren in patients with diabetes mellitus or with renal impairment (ie, GFR <60 mL/min/1.73 m²) Coadministration of neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not admi…
Known interactions (5)
- hydrochlorothiazide-telmisartan + ramipril Major
- aspirin + ramipril Moderate
- cyclosporine + ramipril Moderate
- Omega-3 fatty acids + ramipril Moderate
- prednisolone + ramipril Moderate
Related conditions
Frequently asked questions
What drug class is ramipril?
ramipril belongs to: Cardiovascular.
How does ramipril work?
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
What are the common side effects of ramipril?
Dizziness, Headache, Nausea, Hypotension, Cough, Angina pectoris
Which drugs interact with ramipril?
hydrochlorothiazide-telmisartan, aspirin, cyclosporine, Omega-3 fatty acids, prednisolone
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